T-cell response to my mycobacterial antigens in lepromatous and tuberculoid leprosy
Mem. Inst. Oswaldo Cruz
;
82(supl.2): 153-157, 1987. tab
Artículo
en Inglés
| LILACS
| ID: lil-623777
ABSTRACT
We showed that a large fraction of lepromatous patients do harbor helper-type circulating T-cells that can be activated in vitro by Mycobacterium leprae. M. leprae and PPD triggered T-cell lines could be then obtained from both tuberculoid and lepromatous patients. The proliferative response of these helper T-cells is predominantly directed against epitopes shared by several species of mycobacteria, in lepromatous patients as well as in tuberculoid patients, but species specific T-cells are also present. When presented in the context of M. leprae, these cross reactive epitopes usually fail to stimulate the T-cell lines of lepromatous patients, because of the contamination of the lines by supressor T-cells actavable by M. leprae. In one lepromatous patient, PPD and M. leprae reactive T-cell lines and clones (of the CD4 phenotype), exhibited a strong cytotoxic activity to autologous target cells coated with antigen the relevance of this phenomenon to the pathophysiology of lepromatous leprosy remains however unknown.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Linfocitos T
/
Lepra Tuberculoide
Límite:
Humanos
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
1987
Tipo del documento:
Artículo
/
Congreso y conferencia
País de afiliación:
Francia
Institución/País de afiliación:
Institut Pasteur/FR
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