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Expression of non-TLR pattern recognition receptors in the spleen of BALB/c mice infected with Plasmodium yoelii and Plasmodium chabaudi chabaudi AS
Rosanas-Urgell, Anna; Martin-Jaular, Lorena; Ricarte-Filho, Julio; Ferrer, Mireia; Kalko, Susana; Kimura, Edna; del Portillo, Hernando A.
  • Rosanas-Urgell, Anna; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo. BR
  • Martin-Jaular, Lorena; Universitat de Barcelona. Hospital Clínic. Barcelona Centre for International Health Research. Barcelona. ES
  • Ricarte-Filho, Julio; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Biologia Celular. São Paulo. BR
  • Ferrer, Mireia; Universitat de Barcelona. Hospital Clínic. Barcelona Centre for International Health Research. Barcelona. ES
  • Kalko, Susana; Institut d'Investigacions Biomèdiques August Pi i Sunyer. Hospital Clinic. Bioinformatics Unit. Barcelona. ES
  • Kimura, Edna; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Biologia Celular. São Paulo. BR
  • del Portillo, Hernando A; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo. BR
Mem. Inst. Oswaldo Cruz ; 107(3): 410-415, May 2012. ilus, graf, tab
Artículo en Inglés | LILACS | ID: lil-624024
ABSTRACT
The spleen plays a crucial role in the development of immunity to malaria, but the role of pattern recognition receptors (PRRs) in splenic effector cells during malaria infection is poorly understood. In the present study, we analysed the expression of selected PRRs in splenic effector cells from BALB/c mice infected with the lethal and non-lethal Plasmodium yoelii strains 17XL and 17X, respectively, and the non-lethal Plasmodium chabaudi chabaudi AS strain. The results of these experiments showed fewer significant changes in the expression of PRRs in AS-infected mice than in 17X and 17XL-infected mice. Mannose receptor C type 2 (MRC2) expression increased with parasitemia, whereas Toll-like receptors and sialoadhesin (Sn) decreased in mice infected with P. chabaudi AS. In contrast, MRC type 1 (MRC1), MRC2 and EGF-like module containing mucin-like hormone receptor-like sequence 1 (F4/80) expression decreased with parasitemia in mice infected with 17X, whereas MRC1 an MRC2 increased and F4/80 decreased in mice infected with 17XL. Furthermore, macrophage receptor with collagenous structure and CD68 declined rapidly after initial parasitemia. SIGNR1 and Sn expression demonstrated minor variations in the spleens of mice infected with either strain. Notably, macrophage scavenger receptor (Msr1) and dendritic cell-associated C-type lectin 2 expression increased at both the transcript and protein levels in 17XL-infected mice with 50% parasitemia. Furthermore, the increased lethality of 17X infection in Msr1 -/- mice demonstrated a protective role for Msr1. Our results suggest a dual role for these receptors in parasite clearance and protection in 17X infection and lethality in 17XL infection.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Bazo / Plasmodium yoelii / Plasmodium chabaudi / Receptores de Superficie Celular / Lectinas Tipo C / Lectinas de Unión a Manosa / Receptores Toll-Like / Receptores Depuradores / Malaria Límite: Animales Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 2012 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Brasil / España Institución/País de afiliación: Institut d'Investigacions Biomèdiques August Pi i Sunyer/ES / Universidade de São Paulo/BR / Universitat de Barcelona/ES

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Bazo / Plasmodium yoelii / Plasmodium chabaudi / Receptores de Superficie Celular / Lectinas Tipo C / Lectinas de Unión a Manosa / Receptores Toll-Like / Receptores Depuradores / Malaria Límite: Animales Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 2012 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Brasil / España Institución/País de afiliación: Institut d'Investigacions Biomèdiques August Pi i Sunyer/ES / Universidade de São Paulo/BR / Universitat de Barcelona/ES