The activity of echinocandins, amphotericin B and voriconazole against fluconazole-susceptible and fluconazole-resistant Brazilian Candida glabrata isolates
Mem. Inst. Oswaldo Cruz
;
107(3): 433-436, May 2012. tab
Artículo
en Inglés
| LILACS
| ID: lil-624029
ABSTRACT
The extensive use of azole antifungal agents has promoted the resistance of Candida spp to these drugs. Candida glabrata is a problematic yeast because it presents a high degree of primary or secondary resistance to fluconazole. In Brazil, C. glabrata has been less studied than other species. In this paper, we compared the activity of three major classes of antifungal agents (azoles, echinocandins and polyenes) against fluconazole-susceptible (FS) and fluconazole-resistant (FR) C. glabrata strains. Cross-resistance between fluconazole and voriconazole was remarkable. Among the antifungal agents, the echinocandins were the most effective against FS and FR C. glabrata and micafungin showed the lowest minimal inhibitory concentrations.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Pirimidinas
/
Triazoles
/
Fluconazol
/
Anfotericina B
/
Candida glabrata
/
Equinocandinas
/
Antifúngicos
Límite:
Humanos
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2012
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Complexo Hospitalar Santa Casa de Misericórdia/BR
/
Universidade Federal de Santa Maria/BR
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