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Reversal of CRF- and stress-induced anorexia by an ayurvedic formulation
Kulkarni, V. S.; Surana, S. J..
  • Kulkarni, V. S.; R. C. Patel Institute of Pharmaceutical Education and Research. IN
  • Surana, S. J.; R. C. Patel Institute of Pharmaceutical Education and Research. IN
Rev. bras. farmacogn ; 22(2): 404-411, Mar.-Apr. 2012. graf
Artículo en Inglés | LILACS | ID: lil-624646
ABSTRACT
Trikatu churna is one of the commonly used Ayurvedic formulations in the traditional system of medicine in India for the treatment of agnimandya, i.e. anorexia. Trikatu contains equal amounts of finely powdered rhizomes of Zingiber officinale Roscoe (Zingiberaceae) and fruits of Piper longum L. and Piper nigrum L. (Piperaceae). The chief objective of the study was to determine the antianorectic effects of three drugs individually and to compare these effects with the effect of Trikatu. The activity of the drugs was studied after anorexia was induced in rats by (1) physical stress arising from immobilization for 60 min; (2) intraperitoneal injection of Escherichia coli lipopolysaccharide (LPS, 100 μg/kg body weight); and (3) intraperitoneal administration of fluoxetine (8 mg/kg body weight). Similar doses of the extracts were tested on freely feeding rats and on rats that had been deprived of food for 20 h. Corticotrophin-releasing factor (CRF, 0.3 μg/rat) can induce anxiogenic-like behavior and reduced food intake. This model was also studied, and the results were compared. The components of Trikatu churna failed to individually reverse the inhibition of feeding. In contrast, Trikatu churna pretreatment reversed stress-, fluoxetine- and CRF-induced anorexia. The study provides strong evidence of the synergistic action of Ayurvedic formulas and also proves the ability of Trikatu churna to reduce stress and CRF-induced anorexia.


Texto completo: Disponible Índice: LILACS (Américas) Tipo de estudio: Estudio pronóstico Idioma: Inglés Revista: Rev. bras. farmacogn Asunto de la revista: Farmacia Año: 2012 Tipo del documento: Artículo País de afiliación: India Institución/País de afiliación: R. C. Patel Institute of Pharmaceutical Education and Research/IN

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Texto completo: Disponible Índice: LILACS (Américas) Tipo de estudio: Estudio pronóstico Idioma: Inglés Revista: Rev. bras. farmacogn Asunto de la revista: Farmacia Año: 2012 Tipo del documento: Artículo País de afiliación: India Institución/País de afiliación: R. C. Patel Institute of Pharmaceutical Education and Research/IN