Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats
Rev. bras. farmacogn
;
22(3): 663-668, May-June 2012. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-624695
ABSTRACT
This work presents the observed changes in Wistar rats under long treatment (thirteen weeks) with different oral doses of the ethanolic extract (EE) from Jatropha gossypiifolia L., Euphorbiaceae. The most significant toxic signs indicated a reduction of the activity in the central nervous system and digestive disturbances. The histopathological analysis shows hepatotoxity and pulmonary damages. The lethality was 46.6% among males under the higher experimental dose (405 mg/kg) and 13.3% both in females under the higher dose and among the animals treated with 135 mg/kg of the product. These data show the significant oral chronic toxicity of EE of J. gossypiifolia in rats.
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Idioma:
Inglés
Revista:
Rev. bras. farmacogn
Asunto de la revista:
Farmacia
Año:
2012
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal da Paraíba/BR
/
Universidade Federal de Campina Grande/BR
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