Identificación clínica y patológica de las diversas formas de la enfermedad de Creutzfeldt Jakob en Chile / Clinical and pathologic identification of different forms of Creutzfeldt Jakob disease in Chile
Rev. méd. Chile
;
140(2): 161-168, feb. 2012. ilus, graf, tab
Artículo
en Español
| LILACS
| ID: lil-627622
ABSTRACT
Background:
The identification of clinical and pathological forms of Creutzfeldt Jakob Disease (CJD) started with the first cases of the disease. Genetic and biomolecular prion status assessment are allowing now a better classification.Aim:
To identify the clinical forms of the disease that exist in Chile, based on clinical and neuropathological data. Patients andMethods:
Review of records of 40 patients with CJD in whom a complete history, clinical details and neuropathological studies were available. Clinical aspects were grouped into five categories behavioral and cognitive changes, sleep and alertness, visual impairment, motor disturbances, myoclonus and epilepsy. The neuropathological examination in each case allowed us to evaluate the damage of 13 areas of the central nervous system.Results:
Five forms of CJD were identified. The classic form was present in 28 patients (70%), the Heidenhain form was present in five (12.5%), the ataxic form in four (10%), the form with Kuru plaques in two (5%) and the Vacuolar was present in one patient (2.5%).Conclusions:
The variety and forms of CJD in Chile do not differ substantially from those found abroad.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Síndrome de Creutzfeldt-Jakob
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Chile
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2012
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Universidad de Chile/CL
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