Linfoma marginal del bazo asociado a acidosis láctica tipo B: Caso clínico / Type B lactic acidosis associated with marginal lymphoma of the spleen: Report of one case
Rev. méd. Chile
;
140(2): 236-242, feb. 2012. ilus, tab
Artículo
en Español
| LILACS
| ID: lil-627633
ABSTRACT
Lactic acidosis in the absence of hypoxia or tissue hypoperfusion (type B) is very rare and is associated with the use of some drugs or malignancy. We report a 79-year-old woman, with a marginal non-Hodgkin's lymphoma of the spleen that was subjected to a splenectomy one year ago. She presented with unexplained tachypnea associated with pancytopenia and elevation of IgM to 10 times over the higher normal limit. Laboratory tests showed the presence of metabolic acidosis and high lactic acid levels in the absence of infection, tissue hypoxia or hypoperfusion. She was treated with sodium bicarbonate and steroids without obtaining a reduction in lactate levels. Twelve days after admission, a single dose of Rituximab quickly normalized lactate concentrations and platelet count. After the fourth dose of Rituximab, pancytopenia disappeared and IgM fell to 25% of its baseline concentration.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Neoplasias del Bazo
/
Acidosis Láctica
/
Linfoma no Hodgkin
Tipo de estudio:
Estudio diagnóstico
/
Factores de riesgo
Límite:
Anciano
/
Femenino
/
Humanos
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2012
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Hospital Naval A. Nef/CL
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