Linfoma relacionado a infección por virus de la inmunodeficiencia humana en un hospital público de Santiago, Chile / HIV-related lymphoma in a public hospital in Chile. Analysis of 55 cases
Rev. méd. Chile
;
140(2): 243-250, feb. 2012. ilus, tab
Artículo
en Español
| LILACS
| ID: lil-627634
ABSTRACT
Background:
Cancer is the third cause of death in patients infected with human immunodeficiency virus (HIV) and lymphoma is the most common type.Aim:
To describe the clinical characteristics, histology, risk factors and prognosis of these patients, in a Chilean public hospital in Chile. Material andMethods:
Records of 55 patients (45 males) aged between 23 and 67years with lymphoma and HIV positive serology, diagnosed between 1992-2008, were reviewed.Results:
Six patients (11%) had Hodgkin lymphoma (HL) and the rest, non-Hodgkin lymphoma (NHL). B-cell phenotype constituted 83.7% of NHL cases. The most common subtypes of all the lymphoma were diffuse large B cell lymphoma in 24 cases (43.6%), Burkitt lym-phoma in 12 cases (21.8%), andplasmablastic lymphoma in 5 cases (9.1%). Thirty five patients (64%) underwent curative intended chemotherapy (CT) concomitantly with highly active antiretroviral therapy (HAART). Three year survival of the whole cohort was 27%. By multivariate analysis, the most important prognostic factors for long term survival, were complete responses to CT, (p < 0.01) and a low international prognostic index (IPI) score for NHL, (p = 0.01). HAART, histologic subtype and CD4 lymphocyte count at diagnosis, did not influence survival.Conclusions:
The most important prognostic factors for HIV patients with lymphoma, were achieving CR with CT and low IPI score. Prognosis remains poor, even with HAART therapy.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Enfermedad de Hodgkin
/
Seropositividad para VIH
/
Linfoma Relacionado con SIDA
Tipo de estudio:
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Chile
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2012
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Hospital del Salvador/CL
/
Universidad de Chile/CL
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