Tissue damage markers in experimental Chagas' disease

RESUMO

Malondialdehydemia (MDA),, measurements of heart and liver tissue damage (TDU), plasma activity of heart alfa - hydroxybutyrate dehydrogenase (LDH1) and liver lactate dehydrogenase (LDH5) were determined in non-infected mice and in mice infected with 10*5 T. cruzi, Y strain, bloodstream trypomastigotes. All the parameters measured were increased (P < 0,01) in infected mice 8 days after intraperitoneal inoculation. The results indicate that plasma MDA levels can serve as a useful indicator of the systemic tissue injury found in chagas' disease