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Cytotoxicity of Southeast Asian snake venoms
Jamunaa, A; Vejayan, J; Halijah, I; Sharifah, S. H; Ambu, S.
  • Jamunaa, A; University of Malaya. Institute of Biological Sciences. Kuala Lumpur. MY
  • Vejayan, J; Monash University. School of Medicine and Health Sciences. Bandar Sunway. MY
  • Halijah, I; University of Malaya. Institute of Biological Sciences. Kuala Lumpur. MY
  • Sharifah, S. H; Monash University. School of Medicine and Health Sciences. Bandar Sunway. MY
  • Ambu, S; International Medical University. Kuala Lumpur. MY
J. venom. anim. toxins incl. trop. dis ; 18(2): 150-156, 2012. graf, tab
Artículo en Inglés | LILACS, VETINDEX | ID: lil-639473
ABSTRACT
Cytotoxicity of venoms from eleven medically important snakes found in Southeast Asia (Naja kaouthia, Naja siamensis, Naja sumatrana, Ophiophagus hannah, Bungarus candidus, Bungarus fasciatus, Enhydrina schistosa, Calloselasma rhodostoma, Trimeresurus purpureomaculatus and Tropidolaemus sumatranus) was determined, based on the MTS cytotoxicity assay, which determines the survival of viable cells in monolayer MDCK and Vero cell cultures upon exposure to the snake venoms. Snake venom toxicity was expressed as the venom dose that killed 50% of the cells (CTC50) under the assay conditions. Venoms of C. rhodostoma (2.6 µg/mL, 1.4 µg/mL) and O. hannah were the most cytotoxic (3.8 µg/mL, 1.7 µg/mL) whereas N. siamensis venom showed the least cytotoxicity (51.9 µg/mL, 45.7 µg/mL) against Vero and MDCK cells, respectively. All the viper venoms showed higher cytotoxic potency towards both Vero and MDCK cell lines, in comparison to krait and cobra venoms. E. schistosa did not cause cytotoxicity towards MDCK or Vero cells at the tested concentrations. The cytotoxicity correlates well with the known differences in the composition of venoms from cobras, kraits, vipers and sea snakes.(AU)
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Venenos de Serpiente / Elapidae / Citotoxicidad Inmunológica / Naja naja Límite: Animales Idioma: Inglés Revista: J. venom. anim. toxins incl. trop. dis Año: 2012 Tipo del documento: Artículo Institución/País de afiliación: International Medical University/MY / Monash University/MY / University of Malaya/MY

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Venenos de Serpiente / Elapidae / Citotoxicidad Inmunológica / Naja naja Límite: Animales Idioma: Inglés Revista: J. venom. anim. toxins incl. trop. dis Año: 2012 Tipo del documento: Artículo Institución/País de afiliación: International Medical University/MY / Monash University/MY / University of Malaya/MY