Induction of mitotic crossing-over in diploid strains of Aspergillus nidulansusing low-dose X-rays
Genet. mol. res. (Online)
;
7(2): 467-475, 2008.
Artículo
en Inglés
| LILACS
| ID: lil-640991
ABSTRACT
As a contribution towards detecting the genetic effects of low doses of genotoxic physical agents, this paper deals with the consequences of low-dose X-rays in the Aspergillus nidulans genome. The irradiation doses studied were those commonly used in dental clinics (1-5 cGy). Even very low doses promoted increased mitotic crossing-over frequencies in diploid strains heterozygous for several genetic markers including the ones involved in DNA repair and recombination mechanisms. Genetic markers of several heterozygous strains were individually analyzed disclosing that some markers were especially sensitive to the treatments. These markers should be chosen as bio-indicators in the homozygotization index assay to better detect the recombinogenic/carcinogenic genomic effects of low-dose X-rays.
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Aspergillus nidulans
/
Rayos X
/
Intercambio Genético
/
Mitosis
Idioma:
Inglés
Revista:
Genet. mol. res. (Online)
Asunto de la revista:
Biologia Molecular
/
Genética
Año:
2008
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
Institución/País de afiliación:
Centro Universitário Moura Lacerda/BR
/
Universidade de Franca/BR
/
Universidade de São Paulo/BR
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