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Expression of Rap1GAP in human myeloid disease following microarray selection
Qi, X; Chen, Z; Qian, J; Cen, J; Gu, M.
  • Qi, X; Soochow University. Jiangsu Institute of Hematology. Leukemia Research Division. Suzhou. CN
  • Chen, Z; Soochow University. Jiangsu Institute of Hematology. Leukemia Research Division. Suzhou. CN
  • Qian, J; Soochow University. Jiangsu Institute of Hematology. Leukemia Research Division. Suzhou. CN
  • Cen, J; Soochow University. Jiangsu Institute of Hematology. Leukemia Research Division. Suzhou. CN
  • Gu, M; Soochow University. Jiangsu Institute of Hematology. Leukemia Research Division. Suzhou. CN
Genet. mol. res. (Online) ; 7(2): 379-387, 2008. tab, ilus
Artículo en Inglés | LILACS | ID: lil-641001
ABSTRACT
To find the underlying causes of primary myelodysplastic syndrome (MDS), the gene expression profiling of both CD34+ cells and bone marrow mononuclear cells from MDS patients was performed using oligonucleotide microarray and cDNA microarrays, respectively. Several candidate genes which were differentially expressed in MDS patients versus normal controls were selected and confirmed in expanding samples by quantitative real-time reverse transcription-polymerase chain reaction after clustering and bioinformatics analysis. one of these genes, RAP1GAP, was found to be expressed at a significantly higher level in patients with MDS in comparison with those suffering from other hematopoietic diseases including leukemia (P < 0.01). We propose that over-expression of RAP1GAP gene may play a role in the pathogenesis of MDS.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Síndromes Mielodisplásicos / Proteínas Activadoras de GTPasa Límite: Adulto / Femenino / Humanos / Masculino Idioma: Inglés Revista: Genet. mol. res. (Online) Asunto de la revista: Biologia Molecular / Genética Año: 2008 Tipo del documento: Artículo / Documento de proyecto País de afiliación: China Institución/País de afiliación: Soochow University/CN

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Síndromes Mielodisplásicos / Proteínas Activadoras de GTPasa Límite: Adulto / Femenino / Humanos / Masculino Idioma: Inglés Revista: Genet. mol. res. (Online) Asunto de la revista: Biologia Molecular / Genética Año: 2008 Tipo del documento: Artículo / Documento de proyecto País de afiliación: China Institución/País de afiliación: Soochow University/CN