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La corrección de la sustitución excesiva de cortisol mejora la morbilidad en pacientes con hipopituitarismo: un estudio piloto / Correction of Cortisol Overreplacement Ameliorates Morbidities in Patients with Hypopituitarism: A pilot study
Danilowicz, Karina; Bruno, Oscar Domingo; Manavela, Marcos; Gomez, Reynaldo Manuel; Barkan, Ariel.
  • Danilowicz, Karina; Hospital de Clínicas. Division of Endocrinology. Buenos Aires. AR
  • Bruno, Oscar Domingo; Hospital de Clínicas. Division of Endocrinology. Buenos Aires. AR
  • Manavela, Marcos; Hospital de Clínicas. Division of Endocrinology. Buenos Aires. AR
  • Gomez, Reynaldo Manuel; Hospital de Clínicas. Division of Endocrinology. Buenos Aires. AR
  • Barkan, Ariel; University of Michigan. Division of Metabolism, Endocrinology and Diabetes. Ann Arbor. US
Rev. argent. endocrinol. metab ; 46(2): 25-34, abr.-jun. 2009. graf, tab
Artículo en Inglés | LILACS | ID: lil-641954
ABSTRACT
Context Hyporituitarism in adults is known to be associated with deleterious effects on body composition, lipid profile and quality of life (QoL). This was attributed to GH deficiency. The potential role of glucocorticoid overreplacement had never been investigated.

Objective:

To investigate whether reduction in glucocorticoid replacement dose to more physiological one could ameliorate the "AO-GHD"-attributed symptomatology in patients with hypopituitarism.

Design:

Eleven patients with panhypopituitarism taking 20-30 mg/day of hydrocortisone, but on no GH replacement were switched to 10 to 15 mg of hydrocortisone daily. Both basally and 6-12 months later, their body mass index, body composition by dual-energy x-ray absorptiometry, lipid profile, and the score of quality of life, QOL-AGHDA were measured.

Results:

Within 6-12 months of lower hydrocortisone dose, subjects lost an average of 7.1 kg of total body fat and 4.1 kg of abdominal fat. No changes were seen in lean body mass, bone mineral content and HOMA-IR Plasma total cholesterol and triglyceride concentrations decreased significantly (<0.05) and the QoL improved (p=0.018).

Conclusions:

Our pilot study suggests that decreasing the glucocorticoid replacement dose to ~ 15 mg/ day is beneficial in terms of patients' body composition, lipid profile and quality of life.
Asunto(s)

Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Glucocorticoides / Hipopituitarismo Tipo de estudio: Estudios de evaluación Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Inglés Revista: Rev. argent. endocrinol. metab Asunto de la revista: Endocrinologia / Metabolismo Año: 2009 Tipo del documento: Artículo País de afiliación: Argentina / Estados Unidos Institución/País de afiliación: Hospital de Clínicas/AR / University of Michigan/US

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Glucocorticoides / Hipopituitarismo Tipo de estudio: Estudios de evaluación Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Inglés Revista: Rev. argent. endocrinol. metab Asunto de la revista: Endocrinologia / Metabolismo Año: 2009 Tipo del documento: Artículo País de afiliación: Argentina / Estados Unidos Institución/País de afiliación: Hospital de Clínicas/AR / University of Michigan/US