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In vitro study on the interaction of ketotifen fumarate with anhydrous theophylline
Sayeed, Mohammed Aktar; Habib, Razibul; Rahman, Mominur; Banna, Hasan Al; Rana, Sohel.
  • Sayeed, Mohammed Aktar; International Islamic University Chittagong. Department of Pharmacy. Bangladesh. BD
  • Habib, Razibul; East West University. Department of Pharmacy. Bangladesh. BD
  • Rahman, Mominur; International Islamic University Chittagong. Department of Pharmacy. Bangladesh. BD
  • Banna, Hasan Al; International Islamic University Chittagong. Department of Pharmacy. Bangladesh. BD
  • Rana, Sohel; Jahangirnagar University. Department of Pharmacy. Bangladesh. BD
Braz. j. pharm. sci ; 48(2): 211-216, Apr.-June 2012. graf, tab
Artículo en Inglés | LILACS | ID: lil-643013
ABSTRACT
The purpose of the present study was to investigate the interaction between ketotifen fumarate and anhydrous theophylline in aqueous media of various pH (1.2 and 6.8). Using Job's continuous-variation analysis and Ardon's spectrophotomeric measurement methods, the values of the stability constants of theophylline with ketotifen were determined at a fixed temperature (37 ºC) at various pH. The stability constants, ranging between 5.66 and 9.92, were derived from Ardon's plot, indicating that comparatively stable complexes had formed as a result of an interaction between the drugs. However, following the interaction of theophylline with ketotifen, stability constants were <1 at gastric pH (1.2) and intestinal pH (6.8). Concurrent administration of ketotifen and theophylline could result in the formation of a stable complex and this is likely to reduce the therapeutic activities of both drugs.
RESUMO
O objetivo do presente estudo foi investigar a interação entre o fumarato de cetotifeno e a teofilina anidra em meios aquosos com vários pH (1,2 e 6,8). Utilizando a análise da variação contínua de Job e os métodos de medida espectrofotométrica de Ardon, os valores das constantes de estabilidade da teofilina com o cetotifeno foram determinados em temperatura fixa (37 oC) em vários pH. As constantes de estabilidade, variando entre 5,66 e 9,92 derivaram-se a partir do delineamento de Ardon, indicando, comparativamente, que complexos estáveis se formaram como resultado da interação entre os fármacos. Entretanto, seguindo a interação da teofilina com o cetotifeno, as constantes de estabilidade foram <1, em pH gástrico (1,2) e intestinal (8,8). A administração concomitante de cetotifeno e teofilina poderia resultar na formação de complexo estável, o que reduz a atividade terapêutica de ambos os fármacos.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Técnicas In Vitro / Cetotifen Idioma: Inglés Revista: Braz. j. pharm. sci Año: 2012 Tipo del documento: Artículo País de afiliación: Bangladesh Institución/País de afiliación: East West University/BD / International Islamic University Chittagong/BD / Jahangirnagar University/BD

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Técnicas In Vitro / Cetotifen Idioma: Inglés Revista: Braz. j. pharm. sci Año: 2012 Tipo del documento: Artículo País de afiliación: Bangladesh Institución/País de afiliación: East West University/BD / International Islamic University Chittagong/BD / Jahangirnagar University/BD