Coxiella burnetii, the agent of Q fever in Brazil: its hidden role in seronegative arthritis and the importance of molecular diagnosis based on the repetitive element IS1111 associated with the transposase gene
Mem. Inst. Oswaldo Cruz
;
107(5): 695-697, Aug. 2012.
Artículo
en Inglés
| LILACS
| ID: lil-643760
ABSTRACT
Coxiella burnetii is the agent of Q fever , an emergent worldwide zoonosis of wide clinical spectrum. Although C. burnetii infection is typically associated with acute infection, atypical pneumonia and flu-like symptoms, endocarditis, osteoarticular manifestations and severe disease are possible, especially when the patient has a suppressed immune system; however, these severe complications are typically neglected. This study reports the sequencing of the repetitive element IS1111 of the transposase gene of C. burnetii from blood and bronchoalveolar lavage (BAL) samples from a patient with severe pneumonia following methotrexate therapy, resulting in the molecular diagnosis of Q fever in a patient who had been diagnosed with active seronegative polyarthritis two years earlier. To the best of our knowledge, this represents the first documented case of the isolation of C. burnetii DNA from a BAL sample.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Artritis
/
Fiebre Q
/
ADN Bacteriano
/
Secuencias Repetitivas de Ácidos Nucleicos
/
Coxiella burnetii
/
Transposasas
Tipo de estudio:
Estudio diagnóstico
/
Factores de riesgo
Límite:
Adulto
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2012
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Hospital Copa-D'Or/BR
/
Hospital Servidores do Estado/BR
/
Instituto Oswaldo Cruz-Fiocruz/BR
Similares
MEDLINE
...
LILACS
LIS