Antifungal activity of lectins against yeast of vaginal secretion
Braz. j. microbiol
;
43(2): 770-778, Apr.-June 2012. tab
Artículo
en Inglés
| LILACS
| ID: lil-644495
ABSTRACT
Lectins are carbohydrate-binding proteins of non-imune origin. This group of proteins is distributed widely in nature and they have been found in viruses, microorganisms, plants and animals. Lectins of plants have been isolated and characterized according to their chemical, physical-chemical, structural and biological properties. Among their biological activities, we can stress its fungicidal action. It has been previously described the effect of the lectins Dviol, DRL, ConBr and LSL obtained from the seeds of leguminous plants on the growth of yeasts isolated from vaginal secretions. In the present work the experiments were carried out in microtiter plates and the results interpreted by both methods:
visual observations and a microplate reader at 530nm. The lectin concentrations varied from 0.5 to 256µg/mL, and the inoculum was established between 65-70% of trammitance. All yeast samples isolated from vaginal secretion were evaluated taxonomically, where were observed macroscopic and microscopic characteristics to each species. The LSL lectin did not demonstrate any antifungal activity to any isolate studied. The other lectins DRL, ConBr and DvioL, showed antifungal potential against yeast isolated from vaginal secretion. These findings offering offer a promising field of investigation to develop new therapeutic strategies against vaginal yeast infections, collaborating to improve women's health.
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Levaduras
/
Vaginosis Bacteriana
/
Secreciones Corporales
/
Lectinas de Plantas
/
Lectinas
/
Antifúngicos
Tipo de estudio:
Estudios de evaluación
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Braz. j. microbiol
Asunto de la revista:
Microbiologia
Año:
2012
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Fundação Instituto Oswaldo Cruz/BR
/
Universidade Federal de Pernambuco/BR
/
Universidade Federal do Ceará/BR
/
Universidade de São Paulo/BR
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