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Preconditioning of the response to ischemia/ reperfusion-induced plasma leakage in hamster cheek pouch microcirculation
Conceição, Fabiana Gomes da; Conde, Cristiane Maria Simonato; Svensjö, Erik; Bottino, Daniel Alexandre; Bouskela, Eliete.
  • Conceição, Fabiana Gomes da; State University of Rio de Janeiro. Biomedical Center. Laboratory for Clinical and Experimental Research on Vascular Biology. BR
  • Conde, Cristiane Maria Simonato; State University of Rio de Janeiro. Biomedical Center. Laboratory for Clinical and Experimental Research on Vascular Biology. BR
  • Svensjö, Erik; Federal University of Rio de Janeiro. Health Sciences Center. Institute of Biophysics Carlos Chagas Filho. BR
  • Bottino, Daniel Alexandre; State University of Rio de Janeiro. Biomedical Center. Laboratory for Clinical and Experimental Research on Vascular Biology. BR
  • Bouskela, Eliete; State University of Rio de Janeiro. Biomedical Center. Laboratory for Clinical and Experimental Research on Vascular Biology. BR
Clinics ; 67(8): 923-929, Aug. 2012. ilus, graf, tab
Artículo en Inglés | LILACS | ID: lil-647797
ABSTRACT

OBJECTIVE:

Ischemic preconditioning and some drugs can protect tissues from injury by preserving microcirculation. This study evaluated vascular permeability in a hamster cheek pouch preparation using either short ischemic periods or bradykinin as preconditioning stimuli followed by 30 min of ischemia/reperfusion.

METHOD:

Sixty-six male hamsters were divided into 11 groups five combinations of different ischemic frequencies and durations (one, three or five shorts periods of ischemia, separated by one or five minutes) with 10 min intervals between the ischemic periods, followed by 30 min ischemia/reperfusion; three or five 1 min ischemic periods with 10 min intervals between them followed by the topical application of histamine (2 µM); bradykinin (400 nM) followed by 30 min of ischemia/reperfusion; and three control groups (30 min of ischemia/reperfusion or histamine or bradykinin by themselves). Macromolecular permeability was assessed by injection of fluorescein-labeled dextran (FITC-dextran, MW= 150 kDa; 250 mg/Kg body weight), and the number of leaks/cm2 was counted using an intravital microscope and fluorescent light in the cheek pouch.

RESULTS:

Plasma leakage (number of leaks/cm²) was significantly reduced by preconditioning with three and five 1 min ischemic periods, one and three 5 min ischemic periods and by bradykinin. Histamine-induced macromolecular permeability was also reduced after three periods of 5 min of ischemia.

CONCLUSION:

Short ischemic periods and bradykinin can function as preconditioning stimuli of the ischemia/reperfusion response in the hamster cheek pouch microcirculation. Short ischemic periods also reduced histamineinduced macromolecular permeability.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Permeabilidad Capilar / Daño por Reperfusión / Precondicionamiento Isquémico Tipo de estudio: Estudios de evaluación / Estudio pronóstico Límite: Animales Idioma: Inglés Revista: Clinics Asunto de la revista: Medicina Año: 2012 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Federal University of Rio de Janeiro/BR / State University of Rio de Janeiro/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Permeabilidad Capilar / Daño por Reperfusión / Precondicionamiento Isquémico Tipo de estudio: Estudios de evaluación / Estudio pronóstico Límite: Animales Idioma: Inglés Revista: Clinics Asunto de la revista: Medicina Año: 2012 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Federal University of Rio de Janeiro/BR / State University of Rio de Janeiro/BR