Distinct subcellular localization of tRNA-derived fragments in the infective metacyclic forms of Trypanosoma cruzi
Mem. Inst. Oswaldo Cruz
;
107(6): 816-819, set. 2012. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-649500
ABSTRACT
Small non-coding RNAs derived from transfer RNAs have been identified as a broadly conserved prokaryotic and eukaryotic response to stress. Their presence coincides with changes in developmental state associated with gene expression regulation. In the epimastigote form of Trypanosoma cruzi, tRNA fragments localize to posterior cytoplasmic granules. In the infective metacyclic form of the parasite, we found tRNA-derived fragments to be abundant and evenly distributed within the cytoplasm. The fragments were not associated with polysomes, suggesting that the tRNA-derived fragments may not be directly involved in translation control in metacyclics.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Trypanosoma cruzi
/
ARN de Transferencia
/
ARN Protozoario
/
Gránulos Citoplasmáticos
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2012
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Uruguay
Institución/País de afiliación:
Fiocruz/BR
/
Institut Pasteur de Montevideo/UY
/
Universidade Federal do Paraná/BR
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