The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
Mem. Inst. Oswaldo Cruz
;
107(6): 820-823, set. 2012. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-649501
ABSTRACT
The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Inhibidores Enzimáticos
/
Malaria
/
Azul de Metileno
/
Antimaláricos
Límite:
Animales
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2012
Tipo del documento:
Artículo
País de afiliación:
Colombia
/
Francia
/
España
Institución/País de afiliación:
Universidad Nacional de Colombia/CO
/
University of Navarra/ES
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