Upregulation of hsa-miR-125b in HTLV-1 asymptomatic carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis patients
Mem. Inst. Oswaldo Cruz
;
107(6): 824-827, set. 2012. ilus, graf, tab
Artículo
en Inglés
| LILACS
| ID: lil-649502
ABSTRACT
The retrovirus human T lymphotropic virus type 1 (HTLV-1) promotes spastic paraparesis, adult T cell leukaemia and other diseases. Recently, some human microRNAs (miRNAs) have been described as important factors in host-virus interactions. This study compared miRNA expression in control individuals, asymptomatic HTLV-1 carriers and HTLV-1 associated myelopathy (HAM)/tropical spastic paraparesis patients. The proviral load and Tax protein expression were measured in order to characterize the patients. hsa-miR-125b expression was significantly higher in patients than in controls (p = 0.0285) or in the HAM group (p = 0.0312). Therefore, our findings suggest that miR-125b expression can be used to elucidate the mechanisms of viral replication and pathogenic processes.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Paraparesia Espástica Tropical
/
Productos del Gen tax
/
MicroARNs
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2012
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
/
Japón
Institución/País de afiliación:
Fiocruz-Rondônia,/BR
/
Universidade de São Paulo/BR
/
University of the Ryukyus/JP
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