Methylparaben concentration in commercial Brazilian local anesthetics solutions
J. appl. oral sci
;
20(4): 444-448, July-Aug. 2012. ilus
Artículo
en Inglés
| LILACS
| ID: lil-650621
ABSTRACT
OBJECTIVE:
To detect the presence and concentration of methylparaben in cartridges of commercial Brazilian local anesthetics. MATERIAL ANDMETHODS:
Twelve commercial brands (4 in glass and 8 in plastic cartridges) of local anesthetic solutions for use in dentistry were purchased from the Brazilian market and analyzed. Different lots of the commercial brands were obtained in different Brazilian cities (Piracicaba, Campinas and São Paulo). Separation was performed using high performance liquid chromatography (HPLC) with UV-Vis detector. The mobile phase used was acetonitrilewater (7525 - v/v), pH 4.5, adjusted with acetic acid at a flow rate of 1.0 ml.min-1.RESULTS:
When detected in the solutions, the methylparaben concentration ranged from 0.01% (m/v) to 0.16% (m/v). One glass and all plastic cartridges presented methylparaben.CONCLUSION:
1. Methylparaben concentration varied among solutions from different manufacturers, and it was not indicated in the drug package inserts; 2. Since the presence of methylparaben in dental anesthetics is not regulated by the Brazilian National Health Surveillance Agency (ANVISA) and this substance could cause allergic reactions, it is important to alert dentists about its possible presence.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Parabenos
/
Conservadores Farmacéuticos
/
Anestésicos Locales
Tipo de estudio:
Estudio de etiología
Límite:
Humanos
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
J. appl. oral sci
Asunto de la revista:
Odontología
Año:
2012
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
São Leopoldo Mandic Dental School/BR
/
University of Campinas/BR
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