Occurrence of killer Candida glabrata clinical isolates
Braz. j. microbiol
;
43(3): 880-887, July-Sept. 2012. ilus, graf, tab
Artículo
en Inglés
| LILACS
| ID: lil-656648
ABSTRACT
In this work we characterized the occurrence of killer activity in 64 Candida glabrata clinical isolates under different conditions. We found that only 6.25 % of the clinical isolates tested were positive for killer activity against a Saccharomyces cerevisiae W303 sensitive strain. Sensitivity of killer activity to different values of pH and temperatures was analyzed. We found that the killer activity presented by all isolates was resistant to every pH and temperature tested, although optimal activity was found at a range of pH values from 4 to 7 and at 37ºC. We did not observe extrachromosomal genetic elements associated with killer activity in any of the positive C. glabrata isolates. The killer effect was due to a decrease in viability and DNA fragmentation in sensitive yeast.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Saccharomyces cerevisiae
/
Candidiasis
/
Secuencia de Bases
/
Apoptosis
/
Farmacorresistencia Fúngica
/
Candida glabrata
/
Susceptibilidad a Enfermedades
/
Antifúngicos
Tipo de estudio:
Estudios de evaluación
Límite:
Humanos
Idioma:
Inglés
Revista:
Braz. j. microbiol
Asunto de la revista:
Microbiologia
Año:
2012
Tipo del documento:
Artículo
País de afiliación:
México
Institución/País de afiliación:
Instituto Potosino de Investigación Científica y Tecnológica/MX
/
Universidad Veracruzana/MX
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