Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis
Biol. Res
;
45(3): 257-268, 2012. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-659283
ABSTRACT
Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide. Current treatments reduce the relapse rate and the formation of inflammatory lesions in the CNS, but with only temporary and limited success. Despite the presence of endogenous oligodendroglial progenitors (OPCs) and of spontaneous remyelination, at least in early MS its levels and its qualities are apparently insufficient for a sustained endogenous functional repair. Therefore, novel MS therapies should consider not only immunemodulatory but also myelin repair activities. Mesenchymal stem cells (MSCs) represent an attractive alternative to develop a cell-based therapy for MS. MSCs display stromal features and exert bystander immunemodulatory and neuroprotective activities. Importantly, MSCs induce oligodendrocyte fate decision and differentiation/maturation of adult neural progenitors, suggesting the existence of MSC-derived remyelination activity. Moreover, transplanted MSCs promote functional recovery and myelin repair in different MS animal models. Here, we summarize the current knowledge on endogenous mechanisms for remyelination and proposed autologous MSC therapy as a promising strategy for MS treatment.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Trasplante de Células Madre Mesenquimatosas
/
Esclerosis Múltiple
/
Vaina de Mielina
Tipo de estudio:
Estudio pronóstico
Límite:
Adulto
/
Humanos
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2012
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Austria
Institución/País de afiliación:
Paracelsus Medical University/AT
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