The overexpression of the trypanosomatid-exclusive TcRBP19 RNA-binding protein affects cellular infection by Trypanosoma cruzi
Mem. Inst. Oswaldo Cruz
;
107(8): 1076-1079, Dec. 2012. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-660661
ABSTRACT
To characterise the trypanosomatid-exclusive RNA-binding protein TcRBP19, we analysed the phenotypic changes caused by its overexpression. Although no evident changes were observed when TcRBP19 was ectopically expressed in epimastigotes, the metacyclogenesis process was affected. Notably, TcRBP19 overexpression also led to a decrease in the number of infected mammalian cells. These findings suggest that TcRBP19 may be involved in the life cycle progression of the Trypanosoma cruzi parasite.
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Índice:
LILACS (Américas)
Asunto principal:
Trypanosoma cruzi
/
Proteínas Protozoarias
/
Proteínas de Unión al ARN
Límite:
Animales
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2012
Tipo del documento:
Artículo
País de afiliación:
Uruguay
Institución/País de afiliación:
Facultad de Ciencias/UY
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