Learning and survival memory undergoing a permanent bilateral carotid ligation in rats
Acta cir. bras
; 28(2): 102-105, Feb. 2013. graf
Article
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| LILACS
| ID: lil-662356
Biblioteca responsable:
BR1.1
ABSTRACT
PURPOSE:
To evaluate the effect of cerebral hypoxia-ischemia on memory and learning survival of rats submitted to permanent bilateral carotid ligation (PBCL).METHODS:
Twenty-four survivors of PBCL were evaluated after 30 days with regard to memory and learning using a water survival maze. Twenty-three healthy rats were used as control group. The results were expressed by their means and standard error of the mean (SEM). p<0.05 was used for rejecting the null hypothesis. The study was approved by the Ethics Committee for animal investigation.RESULTS:
The mortality rate for the surgery was 44.4%. The latency time to find the survival platform was higher in rats that underwent PBCL (Normal 10.24 ± 1.85s - Study 25.30 ± 4.69s - Mann - Whitney p=0.0388). Additionally, the type of swimming and the spatial stability of the studied rats on the survival platform were compromised in these animals.CONCLUSION:
The permanent bilateral carotid ligation induces change in the learning and survival memory.Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Arteriopatías Oclusivas
/
Arteria Carótida Común
/
Hipoxia-Isquemia Encefálica
/
Aprendizaje
/
Memoria
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Asunto de la revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2013
Tipo del documento:
Article