A comparative study of pentoxifylline effects in adult and aged rats submitted to lung dysfunction by thermal injury
Acta cir. bras
; 28(2): 154-159, Feb. 2013. ilus, graf
Article
en En
| LILACS
| ID: lil-662365
Biblioteca responsable:
BR1.1
ABSTRACT
PURPOSE:
To investigate the protective effects of pentoxifylline against lung injury observed after dorsal scald in aged animals.METHODS:
Adult (eight months old) and aged (20 months old) rats were subjected to thermal injury or sham procedure. The six hours post-trauma animals received pentoxifylline and after 24 hours were euthanatized and lung tissue samples collectedted. The bronchoalveolar lavage fluid was evaluated for total protein content and tumor necrosis factor-alpha cytokine. Malondialdehyde and myeloperoxidase activety in the lung homogenate were measured and a histological lung examination was undertaken.RESULTS:
Burn injury induced oxidative stress in lung homogenate was higher in elderly-burned rats compared to adult-burned rats (p<0.001). Total protein and cytokine in bronchoalveolar lavage increased in the elderly-burned group when compared to the adult-burned group (p<0.001). All parameters decreased in bolth groups treated with pentoxifylline (p<0.05).CONCLUSIONS:
The injury was augmented in elderly rats when compared to adult rats. Damage was reduced with the use of pentoxifylline, however further studies are needed to evaluate the dose-response of the drug.Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Pentoxifilina
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Depuradores de Radicales Libres
/
Lesión Pulmonar
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Asunto de la revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2013
Tipo del documento:
Article
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Project document