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Prophylactic effect of coconut water (Cocos nucifera L.) on ethylene glycol induced nephrocalcinosis in male wistar rat
International Braz J Urol; Gandhi, M.; Aggarwal, M.; Puri, S.; Singla, S.k..
  • Gandhi, M.; Panjab University. University Institute of Engineering and Technology. Department of Biotechnology. Department of Biochemistry. Chandigarh. IN
  • Aggarwal, M.; Panjab University. University Institute of Engineering and Technology. Department of Biotechnology. Department of Biochemistry. Chandigarh. IN
  • Puri, S.; Panjab University. University Institute of Engineering and Technology. Department of Biotechnology. Department of Biochemistry. Chandigarh. IN
  • Singla, S.k.; Panjab University. University Institute of Engineering and Technology. Department of Biotechnology. Department of Biochemistry. Chandigarh. IN
Int. braz. j. urol ; 39(1): 108-117, January-February/2013. tab, graf
Artículo en Inglés | LILACS | ID: lil-670372
ABSTRACT
Purpose Many medicinal plants have been employed during ages to treat urinary stones though the rationale behind their use is not well established. Thus, the present study was proposed to evaluate the effect of coconut water as a prophylactic agent in experimentally induced nephrolithiasis in a rat model. Materials and Methods The male Wistar rats were divided randomly into three groups. Animals of group I (control) were fed standard rat diet. In group II, the animals were administrated 0.75% ethylene glycol in drinking water for the induction of nephrolithiasis. Group III animals were administrated coconut water in addition to ethylene glycol. All the treatments were continued for a total duration of seven weeks. Results and Conclusion Treatment with coconut water inhibited crystal deposition in renal tissue as well as reduced the number of crystals in urine. Furthermore, coconut water also protected against impaired renal function and development of oxidative stress in the kidneys. The results indicate that coconut water could be a potential candidate for phytotherapy against urolithiasis. .
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Cocos / Fitoterapia / Nefrocalcinosis Límite: Animales Idioma: Inglés Revista: Int. braz. j. urol Asunto de la revista: Urología Año: 2013 Tipo del documento: Artículo / Documento de proyecto País de afiliación: India Institución/País de afiliación: Panjab University/IN

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Cocos / Fitoterapia / Nefrocalcinosis Límite: Animales Idioma: Inglés Revista: Int. braz. j. urol Asunto de la revista: Urología Año: 2013 Tipo del documento: Artículo / Documento de proyecto País de afiliación: India Institución/País de afiliación: Panjab University/IN