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Zinc, vitamin A, and glutamine supplementation in Brazilian shantytown children at risk for diarrhea results in sex-specific improvements in verbal learning
Lima, Aldo A. M.; Kvalsund, Michelle P.; Souza, Paula P. E. de; Figueiredo, Ítalo L; Soares, Alberto M.; Mota, Rosa M. S.; Lima, Noélia L.; Pinkerton, Relana C.; Patrick, Peter P.; Guerrant, Richard L.; Oriá, Reinaldo B..
  • Lima, Aldo A. M.; Federal University of Ceará. School of Medicine. Clinical Research Unit and Institute of Biomedicine/Center for Global Health. Department of Physiology and Pharmacology. Fortaleza. BR
  • Kvalsund, Michelle P.; Federal University of Ceará. School of Medicine. Clinical Research Unit and Institute of Biomedicine/Center for Global Health. Department of Physiology and Pharmacology. Fortaleza. BR
  • Souza, Paula P. E. de; Federal University of Ceará. School of Medicine. Clinical Research Unit and Institute of Biomedicine/Center for Global Health. Department of Physiology and Pharmacology. Fortaleza. BR
  • Figueiredo, Ítalo L; Federal University of Ceará. School of Medicine. Clinical Research Unit and Institute of Biomedicine/Center for Global Health. Department of Physiology and Pharmacology. Fortaleza. BR
  • Soares, Alberto M.; Federal University of Ceará. School of Medicine. Clinical Research Unit and Institute of Biomedicine/Center for Global Health. Department of Physiology and Pharmacology. Fortaleza. BR
  • Mota, Rosa M. S.; Federal University of Ceará. School of Medicine. Clinical Research Unit and Institute of Biomedicine/Center for Global Health. Department of Physiology and Pharmacology. Fortaleza. BR
  • Lima, Noélia L.; Federal University of Ceará. School of Medicine. Clinical Research Unit and Institute of Biomedicine/Center for Global Health. Department of Physiology and Pharmacology. Fortaleza. BR
  • Pinkerton, Relana C.; Federal University of Ceará. School of Medicine. Clinical Research Unit and Institute of Biomedicine/Center for Global Health. Department of Physiology and Pharmacology. Fortaleza. BR
  • Patrick, Peter P.; Federal University of Ceará. School of Medicine. Clinical Research Unit and Institute of Biomedicine/Center for Global Health. Department of Physiology and Pharmacology. Fortaleza. BR
  • Guerrant, Richard L.; Federal University of Ceará. School of Medicine. Clinical Research Unit and Institute of Biomedicine/Center for Global Health. Department of Physiology and Pharmacology. Fortaleza. BR
  • Oriá, Reinaldo B.; Federal University of Ceará. School of Medicine. Clinical Research Unit and Institute of Biomedicine/Center for Global Health. Department of Physiology and Pharmacology. Fortaleza. BR
Clinics ; 68(3): 351-358, 2013. ilus, tab
Artículo en Inglés | LILACS | ID: lil-671426
ABSTRACT

OBJECTIVE:

To identify the impact of supplemental zinc, vitamin A, and glutamine, alone or in combination, on long-term cognitive outcomes among Brazilian shantytown children with low median height-for-age z-scores.

METHODS:

A randomized, double-blind, placebo-controlled trial was conducted in children aged three months to nine years old from the urban shanty compound community of Fortaleza, Brazil. Demographic and anthropometric information was assessed. The random treatment groups available for cognitive testing (total of 167 children) were (1) placebo, n = 25; (2) glutamine, n = 23; (3) zinc, n = 18; (4) vitamin A, n = 19; (5) glutamine+zinc, n = 20; (6) glutamine+vitamin A, n = 21; (7) zinc+vitamin A, n = 23; and (8) glutamine+zinc+vitamin A, n = 18. Neuropsychological tests were administered for the cognitive domains of non-verbal intelligence and abstraction, psychomotor speed, verbal memory and recall ability, and semantic and phonetic verbal fluency. Statistical analyses were performed using SPSS, version 16.0. ClinicalTrials.gov NCT00133406.

RESULTS:

Girls receiving a combination of glutamine, zinc, and vitamin A had higher mean age-adjusted verbal learning scores than girls receiving only placebo (9.5 versus 6.4, p = 0.007) and girls receiving zinc+vitamin A (9.5 versus 6.5, p = 0.006). Similar group differences were not found between male study children.

CONCLUSIONS:

The findings suggest that combination therapy offers a sex-specific advantage on tests of verbal learning, similar to that seen among female patients following traumatic brain injury.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Aprendizaje Verbal / Vitamina A / Vitaminas / Zinc / Suplementos Dietéticos / Diarrea / Glutamina Tipo de estudio: Ensayo Clínico Controlado / Estudio de etiología / Estudio pronóstico / Factores de riesgo Límite: Adolescente / Niño / Child, preschool / Femenino / Humanos / Masculino País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Clinics Asunto de la revista: Medicina Año: 2013 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Brasil Institución/País de afiliación: Federal University of Ceará/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Aprendizaje Verbal / Vitamina A / Vitaminas / Zinc / Suplementos Dietéticos / Diarrea / Glutamina Tipo de estudio: Ensayo Clínico Controlado / Estudio de etiología / Estudio pronóstico / Factores de riesgo Límite: Adolescente / Niño / Child, preschool / Femenino / Humanos / Masculino País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Clinics Asunto de la revista: Medicina Año: 2013 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Brasil Institución/País de afiliación: Federal University of Ceará/BR