Fetuin-A levels in hyperthyroidism
Clinics
;
68(3): 379-383, 2013. graf, tab
Artículo
en Inglés
| LILACS
| ID: lil-671430
ABSTRACT
OBJECTIVE:
Fetuin-A is a protein secreted from the liver that inhibits arterial calcification deposition and can contribute to insulin resistance. Hyperthyroidism is also associated with insulin resistance. It is not known whether hyperthyroidism has an effect on fetuin-A levels.METHODS:
We measured fetuin-A levels and homeostasis model of assessment-insulin resistance before hyperthyroidism treatment was initiated and after euthyroidism was achieved. A total of 42 patients diagnosed with hyperthyroidism were enrolled in this study. Fetuin-A, insulin, high-sensitivity C-reactive protein, fasting blood glucose, free T3 (fT3), free T4 (fT4), and thyrotropin were measured before and after euthyroidism was established.RESULTS:
Basal fasting blood glucose, high-sensitivity C-reactive protein, insulin, c-peptide, homeostasis model of assessment-insulin resistance, fT3, fT4 and fetuin-A levels were significantly decreased after euthyroidism was achieved (Table 1). Basal fasting blood glucose (r0.407, p0.008), high-sensitivity C-reactive protein (r0.523, p<0.0001), insulin (r0.479, p0.001), homeostasis model of assessment-insulin resistance (r0.541, p<0.0001), fT3 (r0.492, p0.001) and fT4 (r0.473, p0.002) were positively correlated with basal fetuin-A levels. Basal thyrotropin levels were significantly negatively correlated (r-0.553, p<0.0001) with basal fetuin-A levels.CONCLUSION:
Our findings suggest that hyperthyroidism influences fetuin-A levels.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Hipertiroidismo
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2013
Tipo del documento:
Artículo
País de afiliación:
Turquía
Institución/País de afiliación:
Izmir Bozyaka Teaching and Research Hospital/TR
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