Treatment of advanced seminoma dactinomycin, cyclophosphamide,vinblastine, bleomycin and cisplatinum the VAB-6 protocol

ABSTRACT

Eighteen ppatients with advanced seminoma (stages IIc-III) were with cytoxan 600 mg/m2, vinblastine 4 mg/m2, actinomycin D 1 mg/m2, bleomycin 30 mg, i. v. on day 1, followed by bleomycin 30 mg/day by infusion, days 1-3, and cis-platinum 120 mg/m2 on day 4. 9/18 pts. achieved complete remission and have been followed clinically; no recurrences have occurred in this group. The other 9 pts. had residual masses after 3 cycles of chemotherapy; they were taken to surgery and no viable tumor was found on surgical specimens. Thera were 3 recurrences in this group, always distant from the site of original disease. These patients were successfully treated with salvage chemotherapy and radiotherapy. One of these patients died of hepatic failure un related to his seminoma. All the other patients are alive, at a median follow-up of 50 months. This chemotherapy regimen is effective in curing advanced seminoma