Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy
Braz. oral res
;
27(3): 252-257, May-Jun/2013. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-673245
ABSTRACT
Precise techniques for the measurement of maxillary bone mineral density (BMD) are useful for the early diagnosis of systemic diseases. The aim of this study was to compare in vivo the efficacy of dual-energy x-ray absorptiometry (DXA) and radiographic densitometry for the measurement of BMD after systemic administration of sodium alendronate. Wistar rats were randomly allocated to a control group (n = 5), which received distilled water, and a sodium alendronate group (n = 8), which received two doses of chemically pure sodium alendronate (1 mg/kg) per week. After 8 weeks, the animals were euthanized, the tibias were removed, and the BMD of the proximal tibial metaphysis was analyzed radiographically and by DXA. The data were subjected to statistical analysis by the Kruskal-Wallis test at a significance level of 5%. Both of the techniques revealed that the alendronate-treated group had a significantly higher BMD (p < 0.05) than the control group after 8 weeks of treatment. Comparing the groups with and without alendronate therapy revealed increases of 14.9% and 29.6% in BMD, as detected radiographically and by DXA, respectively. In conclusion, both of the methods were able to detect an increase in BMD of the proximal tibial metaphysis after alendronate therapy.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Densidad Ósea
/
Alendronato
/
Densitometría
/
Conservadores de la Densidad Ósea
Tipo de estudio:
Estudio de tamizaje
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. oral res
Asunto de la revista:
Odontología
Año:
2013
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Univ de São Paulo - USP/BR
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