Study on nano-structured hydroxyapatite/zirconia stabilized yttria on healing of articular cartilage defect in rabbit
Acta cir. bras
;
28(5): 340-345, May 2013. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-674153
ABSTRACT
PURPOSE:
Articular Cartilage has limited potential for self-repair and tissue engineering approaches attempt to repair articular cartilage by scaffolds. We hypothesized that the combined hydroxyapatite and zirconia stabilized yttria would enhance the quality of cartilage healing.METHODS:
In ten New Zealand white rabbits bilateral full-thickness osteochondral defect, 4 mm in diameter and 3 mm depth, was created on the articular cartilage of the patellar groove of the distal femur. In group I the scaffold was implanted into the right stifle and the same defect was created in the left stifle without any transplant (group II). Specimens were harvested at 12 weeks after implantation, examined histologically for morphologic features, and stained immunohistochemically for type-II collagen.RESULTS:
In group I the defect was filled with a white translucent cartilage tissue In contrast, the defects in the group II remained almost empty. In the group I, the defects were mostly filled with hyaline-like cartilage evidenced but defects in group II were filled with fibrous tissue with surface irregularities. Positive immunohistochemical staining of type-II collagen was observed in group I and it was absent in the control group.CONCLUSION:
The hydroxyapatite/yttria stabilized zirconia scaffold would be an effective scaffold for cartilage tissue engineering.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Cicatrización de Heridas
/
Itrio
/
Circonio
/
Materiales Biocompatibles
/
Cartílago Articular
/
Durapatita
/
Nanoestructuras
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2013
Tipo del documento:
Artículo
País de afiliación:
Irán
Institución/País de afiliación:
Islamic Azad University/IR
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