Serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in Central Brazil
Rev. Soc. Bras. Med. Trop
;
46(2): 166-171, Mar-Apr/2013. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-674652
ABSTRACT
Introduction The yellow fever epidemic that occurred in 1972/73 in Central Brazil surprised the majority of the population unprotected. A clinical-epidemiological survey conducted at that time in the rural area of 19 municipalities found that the highest (13.8%) number of disease cases were present in the municipality of Luziânia, State of Goiás. Methods Thirty-eight years later, a new seroepidemiological survey was conducted with the aim of assessing the degree of immune protection of the rural population of Luziânia, following the continuous attempts of public health services to obtain vaccination coverage in the region. A total of 383 volunteers, aged between 5 and 89 years and with predominant rural labor activities (75.5%), were interviewed. The presence of antibodies against the yellow fever was also investigated in these individuals, by using plaque reduction neutralization test, and correlated to information regarding residency, occupation, epidemiological data and immunity against the yellow fever virus. Results We found a high (97.6%) frequency of protective titers (>110) of neutralizing antibodies against the yellow fever virus; the frequency of titers of 1640 or higher was 23.2%, indicating wide immune protection against the disease in the study population. The presence of protective immunity was correlated to increasing age. Conclusions This study reinforces the importance of surveys to address the immune state of a population at risk for yellow fever infection and to the surveillance of actions to control the disease in endemic areas. .
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Índice:
LILACS (Américas)
Asunto principal:
Fiebre Amarilla
/
Virus de la Fiebre Amarilla
/
Enfermedades Endémicas
/
Vacuna contra la Fiebre Amarilla
/
Anticuerpos Neutralizantes
/
Anticuerpos Antivirales
Tipo de estudio:
Estudio de tamizaje
Límite:
Adolescente
/
Adulto
/
Anciano
/
Aged80
/
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2013
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de Brasília/BR
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