Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America
Braz. j. infect. dis
; 17(3): 353-362, May-June 2013. ilus, tab
Article
en En
| LILACS, SES-SP
| ID: lil-676873
Biblioteca responsable:
BR1.1
ABSTRACT
Latin America is the region with the third most AIDS-related cryptococcal meningitis infections globally. Highly active antiretroviral therapy (HAART) has reduced the number of infections; however, the number of deaths and the case-fatality rate continues to be unacceptable. In this review, we focus on the burden of AIDS-related cryptococcosis in Latin America and discuss potential strategies to reduce early mortality from Cryptococcus. In this review, we highlight the importance of (1) earlier HIV diagnosis and HAART initiation with retention-in-care to avoid AIDS; (2) pre-HAART cryptococcal antigen (CRAG) screening with preemptive fluconazole treatment; (3) better diagnostics (e.g. CRAG testing); and (4) optimal treatment with aggressive management of intracranial pressure and induction therapy with antifungal combination. Implementation of these strategies can reduce cryptococcal-related deaths, improve care, and reduce healthcare costs.
Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Meningitis Criptocócica
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Infecciones Oportunistas Relacionadas con el SIDA
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Terapia Antirretroviral Altamente Activa
Límite:
Humans
Idioma:
En
Revista:
Braz. j. infect. dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2013
Tipo del documento:
Article
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Project document