Agregados amiloides: rol en desórdenes de conformación proteica / Amyloid aggregates: role in protein misfolding disorders
Rev. méd. Chile
;
141(4): 495-505, abr. 2013. ilus
Artículo
en Español
| LILACS
| ID: lil-680473
ABSTRACT
Misfolding and aggregation of proteins are the main features of a group of diseases termed Protein Misfolding Disorders (PMDs). PMDs include Alzheimer's disease and Transmissible Spongiform Encephalopathies, among many others. The deposition of protein aggregates is the main responsible for tissue damage and the consequent clinical signs generated in such disorders. In this review, we will focus in the role of protein aggregates in these diseases and in the putative mechanisms by which they exert their toxicity.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Enfermedades Neurodegenerativas
/
Deficiencias en la Proteostasis
Límite:
Humanos
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2013
Tipo del documento:
Artículo
País de afiliación:
Estados Unidos
Institución/País de afiliación:
University of Texas Medical School at Houston/US
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