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Effectiveness of zinc in modulating perinatal effects of arsenic on the teratological effects in mice offspring
Ahmad, Mohammad; Wadaa, Mohammad A. M; Farooq, Muhammad; Daghestani, Maha H; Sami, Ahmed S.
  • Ahmad, Mohammad; King Saud University. College of Nursing. Department of Medical Surgical Nursing. Riyadh. SA
  • Wadaa, Mohammad A. M; King Saud University. College of Nursing. Department of Medical Surgical Nursing. Riyadh. SA
  • Farooq, Muhammad; King Saud University. College of Nursing. Department of Medical Surgical Nursing. Riyadh. SA
  • Daghestani, Maha H; King Saud University. College of Nursing. Department of Medical Surgical Nursing. Riyadh. SA
  • Sami, Ahmed S; King Saud University. College of Nursing. Department of Medical Surgical Nursing. Riyadh. SA
Biol. Res ; 46(2): 131-138, 2013. graf, tab
Artículo en Inglés | LILACS | ID: lil-683989
ABSTRACT
Exposure to arsenic via drinking water is considered as a worldwide problem. Studies have shown that arsenic exposure during pregnancy affects embryogenesis and offspring development in rats and mice. Zinc as a micronutrient regulates many physiological functions, including an antioxidative role under various toxic conditions. However, studies on the perinatal protective effect of zinc on offspring need further attention. The present study was designed to evaluate the potential protective role of zinc in mitigating the adverse effects in the offspring of arsenic exposure during pregnancy. The arsenic (40mg/kg body weight) and zinc (4% w/v) doses formed the only drinking fluid source for the experimental groups of dams during the perinatal period of the experiment. The early development of sensory motor coordination reflexes together with morphological development in the male pups was measured during the weaning period. In adolescence, the offspring were tested for their motor behavior. The enzyme γ-glutamyl transferase (γ-GT) and the oxidative stress indices like reduced glutathione (GSH) and lipid peroxidation (TBARS) were also estimated in the serum of the young adult male mice. Perinatal arsenic exposure caused depletion in body weight gain, delay in morphological development and retardation in the development of all sensory motor reflexes of the pups. In young adults, significant decrease in motor behavior with significant decrease in GSH level in the serum was observed. On the other hand, γ-GT and TBARS were significantly increased in the serum due to arsenic treatment. However, animals exposed to arsenic in the presence of zinc showed a remarkable ameliorating effect of zinc on all observed teratological and biochemical arsenic toxicity in male offspring. It was observed that zinc has an antioxidative role in the perinatal toxicity of arsenic. It is concluded from the present study that zinc consumed during the perinatal period of pregnancy can ameliorate the possible toxicities of arsenic exposure in the offspring by acting as an ameliorative supplement.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Arsénico / Zinc / Estrés Oxidativo / Intoxicación por Arsénico / Feto / Actividad Motora Límite: Animales / Embarazo Idioma: Inglés Revista: Biol. Res Asunto de la revista: Biologia Año: 2013 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Arabia Saudita Institución/País de afiliación: King Saud University/SA

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Arsénico / Zinc / Estrés Oxidativo / Intoxicación por Arsénico / Feto / Actividad Motora Límite: Animales / Embarazo Idioma: Inglés Revista: Biol. Res Asunto de la revista: Biologia Año: 2013 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Arabia Saudita Institución/País de afiliación: King Saud University/SA