Myocardial remodeling and bioelectric changes in tachycardia-induced heart failure in dogs
Braz. j. med. biol. res
;
46(9): 797-802, 19/set. 2013. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-686580
ABSTRACT
In this study, electrical and structural remodeling of ventricles was examined in tachycardia-induced heart failure (HF). We studied two groups of weight-matched adult male mongrel dogs a sham-operated control group (n=5) and a pacing group (n=5) that underwent ventricular pacing at 230 bpm for 3 weeks. Clinical symptoms of congestive HF were observed in both groups. Their hemodynamic parameters were determined and the severity of the HF was evaluated by M-mode echocardiography. Changes in heart morphology were observed by scanning electron and light microscopy. Ventricular action potential duration (APD), as well as the 50 and 90% APD were measured in both groups. All dogs exhibited clinical symptoms of congestive HF after rapid right ventricular pacing for 3 weeks. These data indicate that rapid, right ventricular pacing produces a useful experimental model of low-output HF in dogs, characterized by biventricular pump dysfunction, biventricular cardiac dilation, and non-ischemic impairment of left ventricular contractility. Electrical and structural myocardial remodeling play an essential role in congestive HF progression, and should thus be prevented.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Taquicardia
/
Potenciales de Acción
/
Remodelación Ventricular
/
Insuficiencia Cardíaca
/
Hemodinámica
Tipo de estudio:
Estudio de etiología
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
2013
Tipo del documento:
Artículo
/
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