PTK2 and PTPN11 expression in myelodysplastic syndromes
Clinics
;
68(10): 1371-1375, out. 2013. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-689980
ABSTRACT
OBJECTIVE:
The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from patients with myelodysplastic syndromes.METHODS:
Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions were analyzed by quantitative polymerase chain reaction in bone marrow cells from patients with myelodysplastic syndromes and healthy donors.RESULTS:
Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions did not significantly differ between normal cells and myelodysplastic cells.CONCLUSIONS:
Our data suggest that despite the relevance of focal adhesion kinase and src homology 2 domain-containing protein-tyrosine phosphatase 2 in hematopoietic disorders, their mRNA expression do not significantly differ between total bone marrow cells from patients with myelodysplastic syndromes and healthy donors. .
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Síndromes Mielodisplásicos
/
Células de la Médula Ósea
Tipo de estudio:
Estudio de etiología
/
Estudios de evaluación
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2013
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Hemocentro-Unicamp+BR
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