Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients
Rev. Soc. Bras. Med. Trop
;
46(5): 645-649, Sept-Oct/2013. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-691420
ABSTRACT
Introduction The immune response caused by Mycobacterium leprae is a risk factor for the development of oxidative stress (OS) in leprosy patients. This study aimed to assess OS in leprosy patients before the use of a multidrug therapy. Methods We evaluated the nitric oxide (NO) concentration; antioxidant capacity; levels of malondialdehyde, methemoglobin and reduced glutathione; and the activity of catalase and superoxide dismutase (SOD) in leprosy patients. Results We observed lower SOD activity in these leprosy patients; however, the NO levels and antioxidant capacity were increased. Conclusions The infectious process in response to M. leprae could primarily be responsible for the OS observed in these patients. .
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Estrés Oxidativo
/
Glutatión
/
Lepra
/
Óxido Nítrico
/
Antioxidantes
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2013
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal do Para/BR
Similares
MEDLINE
...
LILACS
LIS