Aplicación de mitomicina C en queloides de las orejas: centro dermatológico y médico-quirúrgico de Cali. 2010-2011 / Application of mitomycin C on keloid of the ears: Medical and Surgical Dermatology Center of Cali 2010-2011

RESUMEN

Los queloides son prominencias que se forman en la piel por crecimientos exagerados del tejido cicatricial en el sitio de una lesión cutánea, que pueden producirse por incisiones quirúrgicas, heridas traumáticas, sitios de vacunación, quemaduras, varicela, acné, radiación, colocación de piercings o incluso pequeñas lesiones o raspaduras. El presente estudio demuestra que la combinación de la resección quirúrgica y la aplicación tópica de mitomicina C es altamente efectiva para evitar la recurrencia de queloides en las orejas…

ABSTRACT

Keloids are skin lesions formed by an overgrowth of scar tissue at the site of injury may be caused by cutaneous surgical incisions, traumatic wounds, vaccination sites, burns, chickenpox, acne, radiation, piercings or even minor injuries or abrasions. Most keloids will flatten and become less noticeable over the years. Extensive keloids may limit the mobility of the hands, feet or limbs and cause aesthetic. The mitomycin A, B and C are a group of cytotoxic antibiotics and antibacterial properties derived from a common structure called mitosana and are produced by species of the genus Streptomyces. The mitomycin C is an antibiotic that was isolated and studied from Streptomyces caespitosus by Hata and other Japanese researchers in 1955 and 1958 by Wakaki and others.2-4 contains a urethane group and a quinone group in its structure and an aziridine ring, which is essential for the antineoplastic activity…