Biomarcadores pronósticos de gravedad del dengue / Biomarkers for the prognosis of severe dengue
Biomédica (Bogotá)
;
33(supl.1): 108-116, set. 2013. graf, tab
Artículo
en Español
| LILACS
| ID: lil-695802
RESUMEN
.
ABSTRACT
Introduction:
There are very few strategies for the early detection of the patients who might develop the severe form of the illness.Objective:
To evaluate the utility of serum levels of some immune response mediators as early biomarkers for the severe dengue prognosis during the early phase of the illness. Materials andmethods:
Using a case-control design nested in a multicenter cohort from the AEDES network (a Colombian multicenter study), we compared TNF a, ST2, TRAIL and IDO levels in samples which were obtained during the early phase of the illness.Results:
ST2, TRAIL and TNF a levels were higher in severe dengue patients compared with uncomplicated patients (p<0.0001), as follows OR=24.8, CI95%= 6.1- 98.0; OR=18.0, CI95%= 4.6-69.1; OR=NC, CI95%= NC, respectively. We did not find statistically significant differences between IDO levels in severe dengue and uncomplicated dengue (p=1.000, OR=1.0, CI95%= 0.2-6.1).Conclusions:
In the early phase of the dengue infection (96 hours), ST2, TRAIL and TNF a quantifications could contribute to the prediction of complications of the illness.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Factor de Necrosis Tumoral alfa
/
Receptores de Superficie Celular
/
Dengue Grave
/
Ligando Inductor de Apoptosis Relacionado con TNF
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
/
Estudio de tamizaje
Límite:
Adolescente
/
Adulto
/
Anciano
/
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Masculino
Idioma:
Español
Revista:
Biomédica (Bogotá)
Asunto de la revista:
Medicina
Año:
2013
Tipo del documento:
Artículo
País de afiliación:
Colombia
Institución/País de afiliación:
Universidad Industrial de Santander/CO
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