New experimental model of exposure to environmental tobacco smoke
Acta cir. bras
;
28(12): 815-819, Dec. 2013. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-695964
ABSTRACT
PURPOSE:
To describe a new model to passive smoking for rodents.METHODS:
Twenty rats were distributed into two study groups (N=10) control group (CG), that was not exposed to tobacco smoke and used as normal standard for biochemical and histological analysis; Experimental Group (EG), that Animals were exposed to the passive smoking; Euthanasia was performed after 14 days of exposure. The serum level of nicotine and histological analysis were performed.RESULTS:
There was a statistical difference on the nicotine serum levels between Experimental and Control group, with level of 286 ±23 nanograma/mL in the EG and undetectable on CG (p<0.01). The histological study suggested the model efficacy producing alveolar destruction and emphysema in the EG compared with the insignificant lesions in the CG's lung.CONCLUSION:
The model of exposure to environmental tobacco smoke for rodents induced easily the changes related to secondhand smoke.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Contaminación por Humo de Tabaco
/
Modelos Animales de Enfermedad
/
Exposición a Riesgos Ambientales
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2013
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
State University/BR
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