Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits
Acta cir. bras
; 28(12): 833-841, Dec. 2013. ilus, tab
Article
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| ID: lil-695967
Biblioteca responsable:
BR1.1
ABSTRACT
PURPOSE:
To compare the incidence of endothelial injury after single-dose or continuous propofol infusion in conventional lipid-based emulsion (LE) versus microemulsion (ME).METHODS:
Forty-two rabbits (2.5-4.5 Kg) were randomly allocated into seven groups of six animals each SHAM- surgical treatment alone; Bolus Control Group - 3 mL-intravenous (IV) bolus of saline; Continuous Infusion Control Group - 3 mL- IV bolus of saline followed by a continuous infusion of 0.2 ml/kg/min for 60 min; Bolus LE Propofol Group - IV bolus of LE propofol (3 mg/kg); Bolus ME Propofol Group - IV ME propofol bolus (3 mg/kg); Continuous LE Propofol Group - IV LE propofol bolus (3 mg/kg) followed by a continuous infusion of 0.2 ml/kg/min for 60 min; Continuous ME Propofol Group - IV ME propofol bolus (3 mg/kg) followed by a continuous infusion of 0.2 ml/kg/min for 60 min.RESULTS:
There were no statistically significant differences between the studied groups in blood pressure, in central venous pressure and in the biochemical profile. No significant differences were found in inflammatory mediators and in tissue analysis between the two emulsions.CONCLUSION:
Microemulsion and lipid-based emulsion propofol had similar inflammatory, biochemical and microscopy profiles. Thus, microemulsion propofol can be used as an alternative to lipid-based emulsion propofol.Palabras clave
Texto completo:
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Índice:
LILACS
Asunto principal:
Endotelio Vascular
/
Propofol
/
Anestésicos Intravenosos
/
Emulsiones Grasas Intravenosas
Tipo de estudio:
Incidence_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Asunto de la revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2013
Tipo del documento:
Article