Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
35(4): 380-386, Oct-Dec. 2013. graf
Artículo
en Inglés
| LILACS
| ID: lil-697333
ABSTRACT
Objective:
To investigate the effects of cannabidiol (CBD) on mitochondrial complex and creatine kinase (CK) activity in the rat brain using spectrophotometry.Method:
Male adult Wistar rats were given intraperitoneal injections of vehicle or CBD (15, 30, or 60 mg/kg) in an acute (single dose) or chronic (once daily for 14 consecutive days) regimen. The activities of mitochondrial complexes and CK were measured in the hippocampus, striatum, and prefrontal cortex.Results:
Both acute and chronic injection of CBD increased the activity of the mitochondrial complexes (I, II, II-III, and IV) and CK in the rat brain.Conclusions:
Considering that metabolism impairment is certainly involved in the pathophysiology of mood disorders, the modulation of energy metabolism (e.g., by increased mitochondrial complex and CK activity) by CBD could be an important mechanism implicated in the action of CBD. .
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Encéfalo
/
Cannabidiol
/
Creatina Quinasa
/
Mitocondrias
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Asunto de la revista:
Psiquiatria
Año:
2013
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade do Extremo Sul Catarinense (UNESC)/BR
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