In situ protocol for the determination of dose-response effect of low-fluoride dentifrices on enamel remineralization
J. appl. oral sci
; 21(6): 525-532, Nov-Dec/2013. graf
Article
en En
| LILACS, BBO
| ID: lil-697811
Biblioteca responsable:
BR1.1
ABSTRACT
No in situ protocol has assessed the dose-response effects of fluoride dentifrices involving low-fluoride formulations. Objective:
To assess the ability of an in situ remineralization model in determining dose-response effects of dentifrices containing low fluoride concentrations ([F]) on bovine enamel. Material andMethods:
Volunteers wore palatal appliances containing demineralized enamel blocks and brushed their teeth and devices with the dentifrices supplied (double-blind, crossover protocol) separately for 3 and 7 days. Surface hardness (SH), integrated subsurface hardness (ΔKHN) and [F] in enamel were determined. Data were analyzed by ANOVA, Tukey's test and Pearson's correlation (p<0.05).Results:
Dose-response relationships were verified between [F] in dentifrices and SH, ΔKHN and enamel [F]. Higher correlation coefficients between enamel [F] and SH and ΔKHN were obtained for the 3-day period. Significant differences in SH and ΔKHN were observed among all groups for the 3-day period, but not between 0-275, 275-550, and 550-1,100 µg F/g dentifrices for the 7-day period, nor between 3- and 7-day periods for the 1,100 µg F/g groups.Conclusions:
Considering that the peak remineralization capacity of the conventional dentifrice (1,100 µg F/g) was achieved in 3 days, this experimental period could be used in future studies assessing new dentifrice formulations, especially at low-fluoride concentrations. .Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Remineralización Dental
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Desmineralización Dental
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Esmalte Dental
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Dentífricos
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Fluoruros
Tipo de estudio:
Clinical_trials
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Prognostic_studies
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
J. appl. oral sci
Asunto de la revista:
ODONTOLOGIA
Año:
2013
Tipo del documento:
Article