Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients
Rev. bras. hematol. hemoter
;
35(6): 414-416, 2013. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-699991
ABSTRACT
Background: The inflammatory background of patients influences the process of alloimmunization against red blood cell antigens. Proof of this statement to clinical practice is still lacking. Objective: The aim of this study was to verify whether factors related to disease severity and inflammatory status of cancer patients can predict alloimmunization. Methods: This was a case-control study in which alloimmunized oncologic patients treated between 2009 and 2012 were compared with a non-alloimmunized control group regarding the severity of the disease (metastasis/performance status/body mass index) and C-reactive protein levels. Results: The groups did not differ significantly in terms of C-reactive protein, Eastern Cooperative Oncology Group (ECOG)/Karnofsky performance status, presence of metastasis and body mass index. Conclusion: It is not possible to predict alloimmunization in cancer patients based on severity of illness and inflammatory markers. Strategies of screening patients by phenotyping blood based on these criteria are not justified. .
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Transfusión Sanguínea
/
Transfusión de Sangre Autóloga
/
Proteína C-Reactiva
/
Transfusión de Eritrocitos
/
Alergia e Inmunología
/
Fenómenos del Sistema Inmunológico
/
Isoanticuerpos
/
Neoplasias
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Rev. bras. hematol. hemoter
Asunto de la revista:
Hematología
Año:
2013
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Hemocentro de Sao Paulo/BR
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