Alloxan diabetes alters the tensile strength, morphological and morphometric parameters of abdominal wall healing in rats
Acta cir. bras
;
29(2): 118-124, 02/2014. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-702525
ABSTRACT
To investigate the effects of alloxan diabetes on the abdominal wall healing of rats undergoing laparotomy. METHODS:
Ninety-six male Wistar rats weighing between 200 and 300 grams, divided into two groups non-diabetic group (G1) and another with untreated diabetes (G2). Three months after diabetes induction, the animals underwent a 5cm-long- laparotomy and 5.0 nylon monofilament suture. After the surgery, 12 animals from each group were euthanized on days 4, 14, 21 and 30 corresponding to the moments M1, M2, M3 and M4. In each moment a fragment of the abdominal wall containing the scar was removed for tensile strength measurement, histological and morphometric study. Clinical and biochemical parameters were also analyzed.RESULTS:
G2 animals showed parameters compatible with severe diabetes and decreased plasma levels of insulin. The tensile strength in G2 was significantly smaller in M2 and M4, with a tendency to fall in the other two. Through light microscope, diabetic animals showed more difficulty to increase collagen density and contraction. G2 animals showed high cellularity of fibroblasts in later healing moments, with collagen thinning in M2 and M4.CONCLUSION:
The abdominal wound healing in untreated diabetic animals was altered and led to a higher incidence of dehiscence and infections.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Resistencia a la Tracción
/
Alloxanum
/
Pared Abdominal
/
Complicaciones de la Diabetes
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2014
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Estadual Paulista/BR
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