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HIV/AIDS-related visceral leishmaniasis: a clinical and epidemiological description of visceral leishmaniasis in northern Brazil
Albuquerque, Leonardo Cordenonzi Pedroso de; Mendonca, Iatan Rezende; Cardoso, Polyana Nascimento; Baldacara, Leonardo Rodrigo; Borges, Myrlena Regina Machado Mescouto; Borges, Joelma da Costa; Pranchevicius, Maria Cristina da Silva.
  • Albuquerque, Leonardo Cordenonzi Pedroso de; Universidade Federal do Tocantins. Palmas. BR
  • Mendonca, Iatan Rezende; Universidade Federal do Tocantins. Palmas. BR
  • Cardoso, Polyana Nascimento; Universidade Federal do Tocantins. Palmas. BR
  • Baldacara, Leonardo Rodrigo; Universidade Federal do Tocantins. Palmas. BR
  • Borges, Myrlena Regina Machado Mescouto; Universidade Federal do Tocantins. Palmas. BR
  • Borges, Joelma da Costa; Universidade Federal do Tocantins. Palmas. BR
  • Pranchevicius, Maria Cristina da Silva; Universidade Federal do Tocantins. Palmas. BR
Rev. Soc. Bras. Med. Trop ; 47(1): 38-46, Jan-Feb/2014. tab, graf
Artículo en Inglés | LILACS | ID: lil-703170
ABSTRACT

Introduction:

This study aimed to describe the main features of visceral leishmaniasis (VL), both related to and independent of human immunodeficiency virus (HIV) infection, in patients who were registered in Tocantins, Brazil.

Methods:

Data from 1,779 new patients with VL, 33 of whom were also infected with HIV, were reviewed.

Results:

The incidence of VL/HIV coinfection increased from 0.32/100,000 inhabitants in 2007 to 1.08/100,000 inhabitants in 2010. VL occurred predominantly in children aged 10 years or younger, while VL/HIV was more common in patients aged between 18 and 50 years. There were more male patients in the VL/HIV group than in the VL group. Relapse rates were also considerably higher in the VL/HIV (9.1%) group than in the VL group (1.5%). Despite a similar clinical presentation, VL/HIV patients exhibited a higher proportion (24.2%) of concomitant infectious diseases and jaundice. Pentavalent antimonials were used for the initial treatment of VL and VL/HIV infections. However, amphotericin B deoxycholate and liposomal amphotericin B were also widely used in the treatment of VL/HIV coinfection. The mortality rate was higher in the VL/HIV coinfection group (19.4%) than in the VL group (5.4%). Furthermore, the mortality rate due to other causes was significantly higher in the VL/HIV group (12.9%) than in the VL group (0.7%).

Conclusions:

The study showed that the incidence, clinical characteristics and outcomes among the VL and VL/HIV patients in this state are similar to those from other endemic regions, indicating that both infections are emerging with increasing frequency in Brazil. .
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Infecciones Oportunistas Relacionadas con el SIDA / Leishmaniasis Visceral Tipo de estudio: Estudio de incidencia / Estudio pronóstico Límite: Adolescente / Adulto / Niño / Child, preschool / Femenino / Humanos / Lactante / Masculino / Recién Nacido País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Rev. Soc. Bras. Med. Trop Asunto de la revista: Medicina Tropical Año: 2014 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal do Tocantins/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Infecciones Oportunistas Relacionadas con el SIDA / Leishmaniasis Visceral Tipo de estudio: Estudio de incidencia / Estudio pronóstico Límite: Adolescente / Adulto / Niño / Child, preschool / Femenino / Humanos / Lactante / Masculino / Recién Nacido País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Rev. Soc. Bras. Med. Trop Asunto de la revista: Medicina Tropical Año: 2014 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal do Tocantins/BR