Influence of Annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats
Acta cir. bras
;
29(3): 145-150, 03/2014. tab
Artículo
en Inglés
| LILACS
| ID: lil-703522
ABSTRACT
To evaluate the effect of hydroalcoholic extract of A. muricata on biodistribution of two radiopharmaceuticals sodium phytate and dimercaptosuccinic acid (DMSA), both labeled with 99mtechnetium. METHODS:
Twenty four Wistar rats were divided into two treated groups and two controls groups. The controls received water and the treated received 25mg/kg/day of A. muricata by gavage for ten days. One hour after the last dose, the first treated group received 99mTc-DMSA and the second sodium 99mTc-phytate (0.66MBq each group), both via orbital plexus. Controls followed the same protocol. Forty min later, all groups were sacrificed and the blood, kidney and bladder were isolated from the first treated group and the blood, spleen and liver isolated from the second treated group. The percentage of radioactivity per gram of tissue (%ATI/g) was calculated using a gamma counter.RESULTS:
The statistical analysis showed that there was a statistically significant decrease (p<0.05) in the uptake of %ATI/g in bladder (0.11±0.01and1.60±0.08), kidney (3.52±0.51and11.84±1.57) and blood (0.15±0.01and 0.54±0.05) between the treated group and control group, respectively.CONCLUSION:
The A. muricata hydroalcoholic extract negatively influenced the uptake of 99mTc-DMSA in bladder, kidney and blood of rats.
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Solución Hidroalcohólica
/
Radiofármacos
/
Annona
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2014
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal de Campina Grande/BR
/
Universidade Federal do Rio Grande do Norte/BR
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