Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease
Rev. bras. hematol. hemoter
;
36(1): 65-68, Jan-Feb/2014. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-703698
ABSTRACT
Long-term survivors of hematopoietic stem cell transplantation are recognized as a risk group for malignization. Malignant oral neoplasms are increasingly being reported in the literature as a consequence of lesions of chronic graft-versus-host disease, and prolonged multidrug treatment to control its manifestations. This report describes a 43-year-old patient who, after allogeneic bone marrow transplantation, developed an oral squamous cell carcinoma secondary to the use of azathioprine, cyclosporine, prednisone, and tacrolimus, associated with multiorgan chronic graft-versus-host disease involving the oral mucosa, skin, eyes, and liver. This report aims to discuss the possible role of immunosuppressant therapy for chronic graft-versus-host disease on the development of oral squamous cell carcinoma, and the relevance of a close oral follow-up of patients to detect dysplastic or malignant alterations at an early stage.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Neoplasias de la Boca
/
Leucemia Mieloide
/
Trasplante de Médula Ósea
/
Terapia de Inmunosupresión
/
Enfermedad Injerto contra Huésped
Límite:
Humanos
Idioma:
Inglés
Revista:
Rev. bras. hematol. hemoter
Asunto de la revista:
Hematología
Año:
2014
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal do Paraná/BR
Similares
MEDLINE
...
LILACS
LIS